The 2025 Nobel Prizes have highlighted landmark scientific achievements reshaping biotechnology and medicine. The Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering regulatory T cells (Tregs), pivotal in preventing autoimmune diseases and with broad implications for cancer and immunotherapy. Their pioneering work clarified immune tolerance mechanisms, challenging previous beliefs centered on thymic deletion alone. Meanwhile, the Nobel Prize in Chemistry recognized Susumu Kitagawa, Richard Robson, and Omar Yaghi for developing metal-organic frameworks (MOFs), versatile materials with expansive applications in drug delivery and biotechnology. These breakthroughs, announced by renowned academic and scientific institutions, represent foundational advances with broad translational potential across biotech sectors.