The 1000 Genomes Project Long-Read Sequencing Consortium has incorporated PacBio sequencing data to complement existing Oxford Nanopore datasets, aiming for comprehensive telomere-to-telomere genome assemblies across diverse populations. This effort uncovers novel structural variants and improves understanding of complex genomic regions like centromeres and Y chromosomes. Collaborative contributions from multiple institutions and technology providers are creating an unprecedented genomic resource to aid research into human genetic diversity and disease associations.